Related Experiment Video
Updated: Sep 7, 2025
08:31
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
Published on: May 26, 2013
11.1K
Revolutionized virome research using systems microbiology approaches
Suwalak Chitcharoen1,2, Pavaret Sivapornnukul2,3, Sunchai Payungporn2,3
1Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
Experimental Biology and Medicine (Maywood, N.J.)
|June 20, 2022
Summary
New discoveries reveal viruses are everywhere in microbial communities. Viral metagenomics is a powerful tool for studying these viruses, their interactions, and potential applications in biology and medicine.
Area of Science:
- Microbiology
- Virology
- Systems Biology
Background:
- Viruses, both pathogenic and commensal, are increasingly recognized as integral components of microbial communities.
- Advances in systems microbiology have significantly transformed the field of virome research.
Purpose of the Study:
- To review the viral metagenomic approach for studying virus communities.
- To explore virus interactions with other microbes and hosts.
- To summarize the challenges, limitations, and benefits of current virome methodologies.
Main Methods:
- Focus on viral metagenomics as a key approach.
- Review of existing literature on virome studies.
Main Results:
- Viral metagenomics enables comprehensive study of viromes.
- Understanding virus-microbe-host interactions is crucial.
- Current methods offer benefits but also present challenges.
Conclusions:
- Virome studies are advancing rapidly due to new approaches.
- Viral metagenomics provides valuable insights into microbial ecosystems.
- Future applications in biological and clinical fields are promising.
More Related Videos
Related Concept Videos
01:28Biological Methods for Microbial Control
198
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
198
01:29Key Techniques in Microbiology
480
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
480
01:30Environmental Applications of Microorganisms
215
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
215
01:29Microorganisms in Medicine and Therapeutics
311
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
311
01:23The Antiviral System of Bacteria and Archaea: CRISPR
118
CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
118
01:10Retrovirus Life Cycles
46.7K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.7K