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Updated: Sep 7, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Weight change after colectomy for ulcerative colitis.

Matthieu Kouki1, Bénédicte Caron2, Aurélie Malgras3

  • 1Department of Hepatobiliary, Colorectal and Digestive Surgery, University of Nancy, CHU Nancy-Brabois, Nancy, France.

Scandinavian Journal of Gastroenterology
|June 20, 2022
PubMed
Summary

Weight changes after colectomy for ulcerative colitis were studied. Patients regained their healthy weight after surgical management, offering reassurance for those undergoing the procedure.

Keywords:
Ulcerative colitiscolectomysurgeryweight

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Clinical Nutrition

Background:

  • Weight change following colectomy for ulcerative colitis remains poorly understood.
  • Surgical management of ulcerative colitis involves multiple stages, potentially impacting patient weight.

Purpose of the Study:

  • To describe and analyze weight changes throughout the surgical treatment of ulcerative colitis.
  • To provide insights into postoperative weight trajectories for ulcerative colitis patients.

Main Methods:

  • Retrospective analysis of 26 patients undergoing subtotal colectomy, proctectomy with J ileal pouch anal anastomosis, and ileostomy closure for ulcerative colitis.
  • Recording of healthy, preoperative, and postoperative weights at each surgical stage.

Main Results:

  • Median body mass index (BMI) decreased by 8.5% before subtotal colectomy and 10.7% one month post-surgery.
  • BMI significantly increased after proctectomy (8.7% from lowest point) and returned to near-healthy levels (23.2 kg/m² vs. 23.3 kg/m²) after ileostomy closure.
  • The study tracked BMI changes across distinct phases of surgical intervention.

Conclusions:

  • Patients undergoing colectomy for ulcerative colitis regain their pre-illness weight.
  • The findings offer a reassuring outlook for patients considering surgical options for ulcerative colitis.