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2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
Sambashiva Banala1, Ariana N Tkachuk1, Ronak Patel1
1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, United States.
ACS Bio & Med Chem Au
|June 21, 2022
Abstract:
Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties.

