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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer
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Prostate organogenesis.

Andrew Pletcher1,2, Maho Shibata1,2

  • 1Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.

Development (Cambridge, England)
|June 21, 2022
PubMed
Summary

Prostate organogenesis, crucial for male reproductive health, involves androgen regulation and cell communication. Recent advances offer new insights into its development and disease relevance.

Keywords:
Androgen receptorAndrogen signalingCellular heterogeneityProstate cultureProstate developmentProstate organogenesis

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Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Reproductive Medicine

Background:

  • Prostate organogenesis is a complex process starting in embryonic development and continuing through puberty.
  • Androgen signaling and epithelial-mesenchymal interactions are key regulators of prostate development.
  • Understanding prostate development is vital for addressing prostate diseases.

Purpose of the Study:

  • To review recent advancements in understanding prostate organogenesis.
  • To highlight the impact of novel technologies on prostate development research.
  • To contextualize current findings within the broader field of prostate biology.

Main Methods:

  • Genetic-lineage tracing
  • Single-cell RNA sequencing
  • Organoid culture

Main Results:

  • Novel technologies have elucidated androgen regulation mechanisms.
  • Insights into the origins and heterogeneity of prostate epithelial cells.
  • Detailed understanding of cell-cell communication in prostate development.

Conclusions:

  • Recent technological advancements have significantly improved our understanding of prostate organogenesis.
  • This research provides a foundation for investigating prostate diseases.
  • Further exploration of cellular heterogeneity and androgen regulation is warranted.