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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Related Experiment Video

Updated: Sep 7, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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Waking up melanoma.

Amy E Baek1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|June 21, 2022
PubMed
Summary

Dormant melanoma cells in the lung can awaken due to aging-related environmental signals within the stroma. This research explores the mechanisms behind melanoma cell dormancy and reactivation.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Melanoma is a serious form of skin cancer.
  • Dormant cancer cells can evade treatment and cause relapse.
  • The lung is a common site for melanoma metastasis.

Purpose of the Study:

  • To investigate the role of age-related stromal cues in reactivating dormant melanoma cells in the lung.
  • To understand the microenvironmental factors that influence melanoma cell dormancy and progression.

Main Methods:

  • Utilized in vitro cell culture models.
  • Employed advanced imaging techniques to observe melanoma cell behavior.
  • Analyzed molecular markers associated with dormancy and reactivation.

Main Results:

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A 3D Organotypic Melanoma Spheroid Skin Model

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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Related Experiment Videos

Last Updated: Sep 7, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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A 3D Organotypic Melanoma Spheroid Skin Model
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  • Identified specific age-related stromal factors that promote melanoma cell reactivation.
  • Demonstrated that dormant melanoma cells are sensitive to environmental signals.
  • Observed changes in cellular metabolism and signaling pathways upon reactivation.

Conclusions:

  • Age-related stromal cues are critical triggers for dormant melanoma cell reactivation in the lung.
  • Targeting these environmental cues could offer new therapeutic strategies for melanoma metastasis.
  • Further research is needed to elucidate the precise molecular mechanisms involved.