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Reproductive immune microenvironment.

Yonggang Zhou1, Xiaoyu Ding1, Haiming Wei1

  • 1The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China; Institute of Immunology, University of Science and Technology of China, Hefei 230027, China.

Journal of Reproductive Immunology
|June 21, 2022
PubMed
Summary
This summary is machine-generated.

Infertility affects millions globally, with immune factors increasingly recognized. This study introduces the "reproductive immune microenvironment" (RIM) concept, shifting focus to local reproductive tissue immunity for better understanding reproductive health and diseases.

Keywords:
EndometriumInnate immunityOvarian stromaReproductive immune microenvironmentTesticular interstitial space

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Area of Science:

  • Reproductive immunology
  • Immunology of reproduction
  • Reproductive system research

Background:

  • Infertility affects 10-12% of couples worldwide, with growing attention on immunological factors.
  • Past attempts to induce peripheral immune tolerance for pregnancy were unsuccessful, necessitating a shift in research focus.
  • Understanding of the immune system's role in gametogenesis, embryonic development, and early pregnancy has evolved from peripheral to local reproductive tissues.

Purpose of the Study:

  • To provide a holistic overview of immune responses within reproductive organs and tissues.
  • To highlight the importance of regional immunity research for reproductive health.
  • To propose and define the concept of the "reproductive immune microenvironment (RIM)".

Main Methods:

  • Reviewing existing research on the immune microenvironment of the testis, ovary, and uterus.
  • Summarizing common features and basic functions of immune cell niches within reproductive tissues.
  • Synthesizing information to establish the novel concept of RIM.

Main Results:

  • Identified the interstitial space of the testis, ovarian stroma, and endometrium as key immune cell niches.
  • Characterized the common features and basic functions of these tissue microenvironments.
  • Established the "reproductive immune microenvironment (RIM)" as a unifying concept.

Conclusions:

  • The concept of RIM offers a comprehensive description of immune responses in reproductive tissues.
  • RIM provides a macroscopic perspective crucial for understanding the immune etiology of reproductive diseases.
  • Research into RIM is vital for advancing reproductive health and addressing infertility.