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Updated: Sep 7, 2025
14:06
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
18.2K
Normal B-cell ranges in infants: A systematic review and meta-analysis
Francesco Borriello1, Noemi Pasquarelli2, Lisa Law3
1Generate Biomedicines, Cambridge, Mass.
The Journal of Allergy and Clinical Immunology
|June 21, 2022
Summary
This study establishes the first normal reference ranges for B-cell levels in infants during their first year of life. These findings are crucial for monitoring infant immune system development and the impact of therapies.
Area of Science:
- Immunology
- Pediatrics
- Biostatistics
Background:
- B-cell levels are key indicators of infant immune system development.
- No established reference ranges exist for healthy infants' B-cell counts.
- External factors can impact immune development, necessitating reliable B-cell level benchmarks.
Approach:
- Systematic literature review of studies measuring B-cell levels in infants using flow cytometry and CD19 markers.
- Meta-analysis of 28 studies to estimate normal ranges (2.5th-97.5th percentile) by age.
- Continuous age modeling to identify B-cell level peaks and trends.
Key Points:
- Normal B-cell ranges established for cord blood, 0-1 month, 1-6 months, and >6 months old infants.
- Absolute B-cell levels range from 707 cells/μL (cord blood) to 1493 cells/μL (1-6 months).
- B-cell levels peak around week 26 of infancy, with similar trends for percentage estimates.
Conclusions:
- Provides the first age-specific normal reference ranges for infant B-cell levels.
- Essential for assessing infant immune status and response to treatments.
- Facilitates early detection of immune system abnormalities in infants.
Keywords:
B cellCD19cord bloodflow cytometryinfantslower limit of normalnewbornsnormal rangereference rangeMore Related Videos
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