Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

353
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
353
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

77
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
77
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

56
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

505
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
505
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

14.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.9K
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

866
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
866

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Sleep Duration Ratio with a Reduced Risk of Heart Failure: Analysis of the 2017-2023 National Health and Nutrition Examination Survey.

Journal of clinical medicine·2026
Same author

Hypertension in Advanced Chronic Kidney Disease: Saving the Kidneys or the Heart?

Advances in kidney disease and health·2026
Same author

Long-term graft and patient survival following endovascular intervention for renal artery stenosis in transplanted kidneys: a single-center experience.

Annals of vascular surgery·2026
Same author

Factors Influencing Intraocular Pressure Elevation During Hemodialysis.

Translational vision science & technology·2026
Same author

Use of Small Organic Molecules to Improve Pancreatic Beta Cell Resilience to IAPP-Induced Proteotoxic Stress.

International journal of molecular sciences·2026
Same author

A multiagent large language model-based system to simulate the liver transplant selection committee: a retrospective cohort study.

The Lancet. Digital health·2026

Related Experiment Video

Updated: Sep 7, 2025

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

283

Anti-Oxidative Therapy in Diabetic Nephropathy.

Luis F Hernandez1, Natsuki Eguchi1, David Whaley1

  • 1Division of Kidney and Pancreas Transplant, Department of Surgery, University of California, Irvine Medical Center, Orange, CA 92868, USA.

Frontiers in Bioscience (Scholar Edition)
|June 22, 2022
PubMed
Summary

Diabetic nephropathy causes kidney damage via oxidative stress. Antioxidative therapies, particularly targeting the Nrf2 pathway, show promise for treating this progressive kidney disease.

Keywords:
antioxidative therapiesdiabetesdiabetic nephropathyhyperglycemiahypertensionoxidative stressreview

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

278
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

645

Related Experiment Videos

Last Updated: Sep 7, 2025

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

283
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

278
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

645

Area of Science:

  • Nephrology
  • Diabetology
  • Oxidative Stress Research

Background:

  • Chronic kidney disease (CKD) is progressive with no cure.
  • Diabetic nephropathy is a leading cause of end-stage kidney failure.
  • Oxidative stress significantly contributes to kidney damage in diabetic nephropathy.

Purpose of the Study:

  • To review oxidative stress in diabetic nephropathy.
  • To discuss current treatments and their limitations.
  • To explore the potential of antioxidative therapies, focusing on the Nrf2 pathway.

Main Methods:

  • Literature review of oxidative stress mechanisms.
  • Analysis of current therapeutic strategies for diabetic nephropathy.
  • Examination of the role of the Nrf2 pathway in antioxidative defense.

Main Results:

  • Hyperglycemia increases reactive oxygen species (ROS) production, exacerbating oxidative stress.
  • Existing treatments for diabetic nephropathy have limitations in reversing kidney function decline.
  • The Nrf2 pathway presents a potential therapeutic target for managing oxidative stress.

Conclusions:

  • Oxidative stress is a key factor in diabetic nephropathy progression.
  • Targeting antioxidative defense mechanisms, especially the Nrf2 pathway, offers a promising therapeutic avenue.
  • Further research into Nrf2-activating therapies could lead to novel treatments for CKD.