Intestinal absorption of aluminium from antacids: a comparison between hydrotalcite and algeldrate

The intestinal absorption of aluminium (Al) from the antacid hydrotalcite (Ultacit) was compared with that from algeldrate (Algeldratum des-acidans) in 8 healthy human subjects in a cross-over study. The level of Al in serum (AlS) was increased in 7 out of 8 subjects 7 hr after intake of 6 g algeldrate while AlS did not rise after intake of 8 g hydrotalcite--a dose with at least comparable acid-neutralizing capacity--in any of the subjects.