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The 3% Oxygen Desaturation Index is an Independent Risk Factor for Hypertension Among Children with Obstructive Sleep

Hai-Hua Chuang1,2,3, Chao-Yung Wang4, Li-Pang Chuang5

  • 1Department of Family Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Chang Gung University, Taoyuan, Taiwan.

Nature and Science of Sleep
|June 23, 2022
PubMed

Insights

Obstructive sleep apnea (OSA) and obesity are linked to hypertension in children. Intermittent hypoxemia (IH) and higher BMI z-scores independently predict hypertension in pediatric OSA patients, emphasizing weight and oxygenation management.

Area of Science:

  • Pediatric Pulmonology
  • Cardiology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) and obesity are significant risk factors for hypertension.
  • Chronic intermittent hypoxemia (IH) is a key mechanism in OSA comorbidities.
  • The interplay between IH, obesity, and hypertension in children remains poorly understood.

Purpose of the Study:

  • To investigate the associations between IH indices, apnea-hypopnea index, and weight status with hypertension in pediatric OSA patients.
  • To identify independent predictors of hypertension in children with OSA.

Main Methods:

  • Retrospective cross-sectional study of 365 pediatric OSA patients.
  • Collected demographics, anthropometrics, polysomnography, and nocturnal blood pressure data.
  • Utilized multivariate logistic regression with forward selection to identify hypertension predictors.

Main Results:

  • Oxygen desaturation index 3% (ODI3) and BMI z-score were independent continuous predictors of hypertension.
  • Severe OSA and overweight/obesity were independent categorical predictors.
  • In severe IH subgroup, male sex, late childhood/adolescence, overweight/obesity, and sleep hypoxemia predicted hypertension; severe OSA predicted hypertension in the no/mild IH subgroup.

Conclusions:

  • Strong associations exist among IH, overweight/obesity, and hypertension in pediatric OSA.
  • Reducing IH and body weight is crucial for managing hypertension in children with OSA.
Abstract

Keywords:
childrenintermittent hypoxemiaobesityobstructive sleep apneaoxygen desaturation indexpredictive model

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