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Updated: Sep 7, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Antibiotic consumption surveillance in 10 health institutions between 2013 and 2020 in Colombia]
Jobany Castro-Espinosa1, Elisa María Pinzon-Gómez1
1Secretaría de Salud Departamental del Valle del Cauca, Fundación Universitaria San Martin, Colombia.
Background:
The use of antibiotics is the main factor of microbial resistance.
Aim:
To determine the consumption of antibiotics in health care institutions in Santiago de Cali between 2013 and 2020.
Methods:
The methodology of the Defined Daily Dose per 100 beddays was employed. Institutions that had at least 9 annual reports and that the report is greater than 95% were defined as inclusion criteria. In this case, 10 institutions were included.
Results:
Consumption in Intensive Care Units (ICU) was higher than in other units. Ceftriaxone and imipenem were more consumed in units other than ICU, whereas meropenem, piperacillin/tazobactam and vancomycin were more consumed in the ICU. In units other than ICU, two institutions increased the consumption of ceftriaxone, ciprofloxacin and piperacillin/tazobactam and one the consumption of vancomycin, whereas in the ICU, one institution increased the consumption of piperacillin/tazobactam. The endemic range identified that vancomycin located itself in the epidemic zone in one institution.
Conclusion:
The system provided tools for prospective surveillance that showed the need for intervention in institutions.
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