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Updated: Sep 7, 2025

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
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[Herpes Zoster Ophthalmicus presenting as acute headache]
Sandra Marco Campos1, Maria Teresa Tormo Alcañiz1, Inmaculada Vilaplana Mora1
1Hospital Universitario Francisco de Borja, Valencia, España.
Andes Pediatrica : Revista Chilena De Pediatria
|June 23, 2022
Summary
Herpes Zoster Ophthalmicus (HZO) can cause unilateral headaches in children and requires consideration in differential diagnoses. Early recognition and treatment are crucial for managing this rare condition and its potential complications.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Herpes Zoster (HZ), a reactivation of the varicella-zoster virus, is uncommon in children.
- Herpes Zoster Ophthalmicus (HZO) involves the ophthalmic nerve and can manifest as acute headache, necessitating its inclusion in differential diagnoses.
Observation:
- A case study of an 11-year-old girl with unilateral headache presented with HZO.
- Clinical manifestations included vesicular lesions on the forehead, eyelid, nose, and dendritic corneal lesions.
Findings:
- The patient experienced complications such as postherpetic neuralgia and recurrent HZO with acute keratouveitis despite antiviral and gabapentin treatment.
- Vaccination against varicella may offer partial protection against HZO.
Implications:
- HZO should be considered in the differential diagnosis of unilateral headaches in children, particularly with ocular symptoms or a history of chickenpox.
- Prompt diagnosis and management of HZO are vital to prevent severe complications and relapses in pediatric patients.
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