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Updated: Sep 7, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Recent Advances in the Synthesis of Marine-Derived Alkaloids via Enzymatic Reactions
Bi-Shuang Chen1,2, Di Zhang1,2, Fayene Zeferino Ribeiro de Souza3
1School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China.
Abstract:
Alkaloids are a large and structurally diverse group of marine-derived natural products. Most marine-derived alkaloids are biologically active and show promising applications in modern (agro)chemical, pharmaceutical, and fine chemical industries. Different approaches have been established to access these marine-derived alkaloids. Among these employed methods, biotechnological approaches, namely, (chemo)enzymatic synthesis, have significant potential for playing a central role in alkaloid production on an industrial scale. In this review, we discuss research progress on marine-derived alkaloid synthesis via enzymatic reactions and note the advantages and disadvantages of their applications for industrial production, as well as green chemistry for marine natural product research.
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