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Antitumor Potential of Immunomodulatory Natural Products

Genoveffa Nuzzo1, Giuseppina Senese1, Carmela Gallo1

  • 1Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry-CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.

Marine Drugs
|June 23, 2022
PubMed

Insights

Natural products offer a promising avenue for cancer treatment, exhibiting anticancer and immunomodulatory properties. This review explores natural compounds that interact with the immune system to combat tumors.

Area of Science:

  • Pharmacology
  • Immunology
  • Natural Products Chemistry

Background:

  • Cancer remains a leading global cause of mortality, necessitating novel therapeutic strategies.
  • Conventional anticancer drugs often exhibit significant toxicity to healthy cells and organs.
  • Cancer immunotherapy is emerging as a safer and effective complementary approach to chemotherapy.

Purpose of the Study:

  • To review natural products with demonstrated antitumor properties through immune system interaction.
  • To discuss the potential immunomodulatory mechanisms of these natural compounds.
  • To highlight the role of natural products in cancer treatment and immunotherapy.

Main Methods:

  • Literature review of scientific articles and research papers.
  • Analysis of studies focusing on natural products and their interaction with the immune system in cancer.
  • Synthesis of information on antitumor activities and immunomodulatory mechanisms.

Main Results:

  • Numerous natural products possess antitumor activities by modulating immune responses.
  • These compounds offer potential chemo-protective and immunomodulatory benefits.
  • Natural products can be used alone or in combination with conventional cancer therapies.

Conclusions:

  • Natural products represent a valuable source for developing novel anticancer drugs.
  • Their ability to interact with the immune system opens new avenues for cancer immunotherapy.
  • Further research into the mechanisms of action of these compounds is warranted.
Keywords:
anticancerantitumorimmunomodulatorsmarine productsnatural products

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