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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Muscle Recovery and Fatigue01:24

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
282
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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[Fatigue].

Peter Lucassen1, Sonja van Ockenburg2, Rijk Gans2

  • 1Radboudumc, Research Institute of Health Sciences, afd. Eerstelijnsgeneeskunde, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|June 23, 2022
PubMed
Summary
This summary is machine-generated.

Many patients experience unexplained fatigue, with general practitioners identifying causes in only a quarter of cases. Further investigation is crucial for persistent fatigue, especially for conditions like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

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Area of Science:

  • General Practice
  • Internal Medicine
  • Neurology

Background:

  • Fatigue is a common symptom presenting to general practitioners.
  • A significant proportion of fatigue cases remain undiagnosed in primary care settings.

Purpose of the Study:

  • To outline diagnostic approaches for fatigue in primary care.
  • To emphasize the importance of thorough evaluation for persistent fatigue.

Main Methods:

  • Review of diagnostic yields in primary care for fatigue.
  • Recommendations for expanding investigations in prolonged fatigue cases.

Main Results:

  • Somatic causes explain 8% of fatigue, psychosocial causes 16%, with 76% unexplained.
  • Thorough physical examination is essential, even with low somatic prevalence.
  • Extended history, comprehensive blood tests, sleep studies, and specialist referral are indicated for fatigue > 6 months.

Conclusions:

  • General practitioners face challenges in diagnosing fatigue.
  • Systematic investigation is necessary for unexplained and prolonged fatigue.
  • Prognosis for long-term fatigue, particularly ME/CFS, is often poor, necessitating specialized management.