Microparticulated Mefenamic Acid with High Dispersion Stability for Pediatric Dosage Form

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Mefenamic acid (MFA) is a water-insoluble drug commonly formulated as a suspension.
• Current MFA suspensions require vigorous shaking due to poor dispersion stability.
• Previous attempts to improve stability used wet-milling with hydroxypropyl cellulose (HPC), but optimal HPC parameters were unknown.

Purpose of the Study:

• To determine the optimal molecular weight and concentration of HPC for micronizing MFA.
• To evaluate the effect of SDS addition on MFA particle size and suspension properties.
• To identify the ideal combination of HPC-SL and SDS for maximizing MFA suspension dispersion stability.

Main Methods:

• Investigated various molecular weights and concentrations of HPC for MFA micronization.
• Utilized wet-milling techniques for particle size reduction.
• Assessed the impact of sodium dodecyl sulfate (SDS) as a co-surfactant.
• Analyzed particle size and dispersion stability of the prepared MFA suspensions.

Main Results:

• MFA particles were successfully micronized, resulting in finer particles.
• The addition of SDS further reduced particle size compared to HPC alone.
• Optimal dispersion stability was achieved with a mixed aqueous solution of 1.0% HPC-SL and 0.12% SDS.

Conclusions:

• The combination of SDS and 1.0% HPC-SL aqueous solution is optimal for enhancing MFA suspension dispersion stability.
• This formulation significantly improves the physical properties of mefenamic acid suspensions.
• The findings provide a basis for developing more stable and effective MFA drug delivery systems.