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Related Experiment Video

Updated: Sep 6, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Lung Inflammation Is Associated with Preeclampsia Development in the Rat.

Katrina Curtis1, Derek Clarke1, Makayla Hanegan1

  • 1Lung and Placenta Laboratory, Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA.

Cells
|June 24, 2022
PubMed
Summary

Gas6 signaling can induce preeclampsia (PE) in rats, leading to increased lung inflammation and elevated blood pressure. This study highlights the role of Gas6/AXL signaling in maternal lung responses during PE development.

Keywords:
AXLGas6inflammationlungpreeclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Pulmonology
  • Molecular Biology

Background:

  • Preeclampsia (PE) is a serious pregnancy complication with implications for maternal and fetal health.
  • A link between lung disease and PE has been observed.
  • Gas6 protein, found in the lung and placenta, interacts with the AXL receptor tyrosine kinase.

Purpose of the Study:

  • To investigate the role of Gas6/AXL signaling in the maternal lung during the development of preeclampsia.
  • To determine if Gas6 can induce preeclampsia-like symptoms and associated lung inflammation.

Main Methods:

  • Pregnant rats were treated with Gas6 or Gas6 plus an AXL inhibitor (R428).
  • Immunofluorescence, Western blot, and ELISA were used to analyze AXL expression, signaling pathways (ERK, AKT), and inflammatory cytokines.
  • Bronchoalveolar lavage fluid (BALF) was analyzed for inflammatory markers and protein content.

Main Results:

  • Gas6 treatment resulted in increased proteinuria and blood pressure, mimicking PE.
  • AXL expression was elevated in the lungs of Gas6-treated rats.
  • BALF analysis showed increased total protein and inflammatory cytokines in Gas6-treated animals, indicating lung inflammation.
  • Gas6 signaling influenced ERK and AKT pathways in the lung.

Conclusions:

  • Gas6 signaling is sufficient to induce preeclampsia-like conditions in a rat model.
  • PE development mediated by Gas6 is associated with significant inflammation in the maternal lung.
  • The Gas6/AXL pathway is a potential target for understanding and managing PE-related lung complications.