Capturing Subjective Mild Cognitive Decline in Parkinson's Disease
Sara Rosenblum1, Sonya Meyer2, Ariella Richardson3
1Laboratory of Complex Human Activity and Participation (CHAP), Department of Occupational Therapy, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa 3498838, Israel.
Brain Sciences
|June 24, 2022
Summary
Parkinson's disease patients with mild cognitive decline show significant daily functional deficits. These subtle cognitive changes impact daily life and quality of life, highlighting the need for early detection.
Area of Science:
- Neurology
- Neuropsychology
- Gerontology
Background:
- Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
- Cognitive decline is a common non-motor symptom in PD, impacting daily functioning.
- Early detection of mild cognitive decline in PD is crucial for management and prognosis.
Purpose of the Study:
- To assess subjective daily functional cognitive decline in Parkinson's disease patients.
- To identify specific daily activities affected by cognitive changes in PD.
- To correlate daily functional deficits with cognitive status in PD.
Main Methods:
- Cross-sectional study comparing 78 PD patients with 41 healthy controls (aged 40-79).
- Utilized Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Cognitive Functional Rating Scale (CFRS), Daily Living Questionnaire (DLQ), and Time Organisation and Participation Scale (TOPS).
- PD patients categorized into groups with or without suspected mild cognitive decline based on MDS-UPDRS Cognitive Functional (CF) feature scores.
Main Results:
- Significant differences in DLQ and TOPS scores between PD groups with and without mild cognitive decline.
- Specific DLQ and TOPS items explained 35% of the variance in the CF feature.
- A strong correlation was observed between questionnaire results and daily cognitive functional states.
Conclusions:
- Subtle daily functional deficits are detectable in PD patients with suspected mild cognitive decline.
- DLQ and TOPS are valuable tools for assessing cognitive-related functional impairments in PD.
- Identifying these deficits is vital for improving health, quality of life, and predicting dementia risk in PD.
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