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The Treatment of Advanced Melanoma: Therapeutic Update

Alessia Villani1, Luca Potestio1, Gabriella Fabbrocini1

  • 1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.

International Journal of Molecular Sciences
|June 24, 2022
PubMed

Insights

Advanced melanoma (AM) treatment is challenging. Emerging immunotherapies and targeted therapies offer promising, effective, and safe options for managing this complex skin cancer.

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Cutaneous melanoma is a leading cause of skin cancer mortality.
  • Localized melanoma is treatable with surgery, but advanced melanoma (AM) requires novel therapeutic strategies.
  • AM presents challenges due to high mutation rates and immune evasion by cancer cells.

Purpose of the Study:

  • To review and discuss emerging therapies for advanced melanoma management.
  • To provide a comprehensive overview of current treatment options and future perspectives for AM.

Main Methods:

  • Literature review of recent advancements in melanoma pathogenesis.
  • Analysis of novel therapeutic approaches including immunotherapies, targeted therapies, vaccines, small molecules, and combination therapies.

Main Results:

  • Chemotherapeutic agents previously used for AM showed limited efficacy.
  • Emerging therapies like immunotherapies and targeted treatments have revolutionized AM management.
  • These novel approaches demonstrate promising effectiveness and safety profiles.

Conclusions:

  • The management of advanced melanoma has been significantly improved by recent therapeutic innovations.
  • Emerging therapies represent a paradigm shift in treating advanced melanoma, offering better outcomes.
  • Continued research into novel treatment strategies is crucial for further advancing AM care.
Keywords:
immune checkpoint inhibitorsmelanomametastatic melanomasmall moleculestargeted therapyvaccines

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