Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

10.2K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
10.2K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

21
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
21
Anastomoses01:19

Anastomoses

1.3K
In human anatomy, anastomosis refers to a connection or opening between two things, particularly between blood vessels or other tubular structures. The term is derived from the Greek term 'anastomosis,' which means 'outlet' or 'opening.' This natural network of connections plays a critical role in the survival and functionality of the human body.
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They...
1.3K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

36
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
36
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

73
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
73
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

25
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
25

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adapting developmental science for a world of diverse families.

The Behavioral and brain sciences·2026
Same author

Clustered monoallelic mosaicism in twins suggests previously unrecognized path of mutagenesis.

HGG advances·2026
Same author

Challenges and recommendations in establishing national human diversity genomic projects.

Nature methods·2026
Same author

Interdisciplinary vascular genetics evaluations in routine clinical care: insights from a five-year single-center experience.

Langenbeck's archives of surgery·2026
Same author

Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.

Clinical science (London, England : 1979)·2026
Same author

Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromes.

bioRxiv : the preprint server for biology·2026
Same journal

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same journal

Surgical and Transcatheter Approach of a Failed Mitral Valve Repair: A Comprehensive Review on Selecting the Most Suitable Approach.

Journal of clinical medicine·2026
Same journal

Hybrid Metaheuristic Feature Selection for Breast Cancer Detection in Digital Mammography: A Feasibility Study with Nested Validation, Benchmarking, and External Stress Testing.

Journal of clinical medicine·2026
Same journal

Identity Transformation and the Role of Accountability in Recovery from Problematic Pornography Use: A Phenomenological-Hermeneutical Study.

Journal of clinical medicine·2026
Same journal

Does Early Surgical Treatment in Degenerative Cervical Myelopathy Have a Favorable Clinical Outcome and Impact on Quality of Life?

Journal of clinical medicine·2026
Same journal

Shear Wave Elastography in Musculoskeletal Imaging: A Narrative Review.

Journal of clinical medicine·2026
See all related articles

Related Experiment Video

Updated: Sep 6, 2025

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

702

Multiple Arterial Dissections and Connective Tissue Abnormalities.

Philipp Erhart1, Daniel Körfer1, Susanne Dihlmann1

  • 1Department of Vascular and Endovascular Surgery, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

Journal of Clinical Medicine
|June 24, 2022
PubMed
Summary
This summary is machine-generated.

Mild connective tissue abnormalities may be common in patients with multiple arterial dissections. Genetic testing is recommended for recurrent arterial dissections, even without obvious connective tissue disorder signs.

Keywords:
Ehlers–Danlos syndromeMarfan syndromecarotid arteryconnective tissue diseasedissectiongenetics

More Related Videos

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.6K
Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
07:12

Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta

Published on: September 8, 2023

2.8K

Related Experiment Videos

Last Updated: Sep 6, 2025

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

702
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.6K
Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta
07:12

Author Spotlight: Using Point-of-Care Ultrasound for Comprehensive Evaluation of the Abdominal Aorta

Published on: September 8, 2023

2.8K

Area of Science:

  • Genetics
  • Vascular Biology
  • Connective Tissue Diseases

Background:

  • Multiple arterial dissections in different regions are rare in patients with known connective tissue syndromes.
  • This study investigates the hypothesis that mild connective tissue abnormalities are prevalent in such patients.

Purpose of the Study:

  • To explore the prevalence of mild connective tissue abnormalities in patients with multiple arterial dissections.
  • To identify potential genetic underpinnings of recurrent arterial dissections.

Main Methods:

  • Analysis of 4 patients with cervical artery dissection (CeAD) and dissections in other vascular beds.
  • Dermal connective tissue examination via electron microscopy.
  • Whole-exome sequencing and copy number variation (CNV) analysis of patient DNA.

Main Results:

  • Pathologic collagen fibers were observed in dermal biopsies of all three analyzed patients.
  • One patient had a CNV affecting COL3A1 and COL5A2 (Ehlers-Danlos syndrome).
  • Another patient had a CNV in MYH11 (familial thoracic aortic aneurysms and dissections); a third had a COL5A2 missense substitution.

Conclusions:

  • Morphologic alterations in dermal connective tissue were found in three patients.
  • Two patients carried pathogenic variants in genes linked to arterial connective tissue dysfunction.
  • Genetic testing is suggested for recurrent arterial dissections, irrespective of clear phenotypical connective tissue disorder signs.