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Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
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Effect of Malignancy on Semen Parameters
Guy Shrem1, Liat Azani2, Ido Feferkorn3
1IVF Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center, 1st Pasternak St., Rehovot 7661041, Israel.
Life (Basel, Switzerland)
|June 24, 2022
Summary
Cancer significantly impairs sperm quality, affecting concentration, motility, and count. This impacts fertility, even when parameters appear normal by WHO standards.
Area of Science:
- Reproductive Medicine
- Oncology
- Andrology
Background:
- Semen quality assessment is crucial for male fertility evaluations.
- The impact of various cancer types on sperm parameters requires further clarification.
Purpose of the Study:
- To investigate the effects of different histological cancer types on semen quality.
- To compare semen parameters in cancer patients undergoing pre-treatment sperm cryopreservation with control groups.
Main Methods:
- Retrospective analysis of 313 cancer patients (PG-Tx group) undergoing sperm cryopreservation.
- Comparison of semen parameters with a reference limit group (ARL) and fertile men (WHO 2020 data).
- Statistical analysis including linear regression models to assess cancer-specific effects.
Main Results:
- Cancer patients (PG-Tx group) exhibited significantly poorer semen quality compared to the ARL group.
- Key reductions observed: 65.6% in concentration, 72.7% in total count, and significant decreases in motility parameters.
- Germ-cell tumors showed the greatest reduction in motility and concentration, while hematological tumors showed the least.
Conclusions:
- All examined cancer types significantly impair sperm quality parameters.
- Despite median values often falling within WHO normal ranges, the lower percentiles indicate potential fertility issues.
- Cancer diagnosis and treatment significantly affect male reproductive potential, necessitating fertility preservation discussions.
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