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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Updated: Sep 6, 2025

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
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Effect of Malignancy on Semen Parameters.

Guy Shrem1, Liat Azani2, Ido Feferkorn3

  • 1IVF Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center, 1st Pasternak St., Rehovot 7661041, Israel.

Life (Basel, Switzerland)
|June 24, 2022
PubMed
Summary
This summary is machine-generated.

Cancer significantly impairs sperm quality, affecting concentration, motility, and count. This impacts fertility, even when parameters appear normal by WHO standards.

Keywords:
malignancysemen parameterssperm cryopreservation

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Area of Science:

  • Reproductive Medicine
  • Oncology
  • Andrology

Background:

  • Semen quality assessment is crucial for male fertility evaluations.
  • The impact of various cancer types on sperm parameters requires further clarification.

Purpose of the Study:

  • To investigate the effects of different histological cancer types on semen quality.
  • To compare semen parameters in cancer patients undergoing pre-treatment sperm cryopreservation with control groups.

Main Methods:

  • Retrospective analysis of 313 cancer patients (PG-Tx group) undergoing sperm cryopreservation.
  • Comparison of semen parameters with a reference limit group (ARL) and fertile men (WHO 2020 data).
  • Statistical analysis including linear regression models to assess cancer-specific effects.

Main Results:

  • Cancer patients (PG-Tx group) exhibited significantly poorer semen quality compared to the ARL group.
  • Key reductions observed: 65.6% in concentration, 72.7% in total count, and significant decreases in motility parameters.
  • Germ-cell tumors showed the greatest reduction in motility and concentration, while hematological tumors showed the least.

Conclusions:

  • All examined cancer types significantly impair sperm quality parameters.
  • Despite median values often falling within WHO normal ranges, the lower percentiles indicate potential fertility issues.
  • Cancer diagnosis and treatment significantly affect male reproductive potential, necessitating fertility preservation discussions.