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Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

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Tooth-Specific Streptococcus mutans Distribution and Associated Microbiome.

Márcia Dinis¹, William Traynor¹, Melissa Agnello²

¹Section of Pediatric Dentistry, School of Dentistry, University of California, Los Angeles, CA 90095, USA.

|June 24, 2022

Summary

Dental caries is influenced by specific bacteria like Streptococcus mutans, with distinct microbial communities found on individual teeth. Tooth type and development stage impact caries susceptibility.

Keywords:

Streptococcus mutans dental caries dentition stages posterior teeth tooth-associated microbiome

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An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

Area of Science:

Oral microbiology
Dental research
Microbiome analysis

Background:

Dental caries is a common, multifactorial oral disease.
Streptococcus mutans is a key pathogen, but its tooth-level impact is unclear.
Understanding tooth-specific microbiomes is crucial for caries prevention.

Purpose of the Study:

Investigate Streptococcus mutans levels and distribution on posterior teeth.
Analyze tooth-specific microbiomes at different dentition stages.
Correlate microbial findings with tooth-level caries experience.

Main Methods:

Cross-sectional study of 87 posterior teeth from 30 children.
Quantified Streptococcus mutans using qPCR in occlusal plaque.
Performed 16S rRNA sequencing for tooth-specific microbiome analysis.

Main Results:

Streptococcus mutans preferentially colonized first primary and permanent molars.
Significant differences in relative abundance of Neisseria, Streptococcus, Rothia, and Veillonella.
Tooth-level caries experience correlated with reduced microbiome diversity.

Conclusions:

Caries susceptibility varies by tooth type and dentition stage.
Individual species and plaque community composition influence caries risk.
Distinct tooth-specific core microbiomes were identified.