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Related Experiment Video

Updated: Sep 6, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Keratoconus: A Biomechanical Perspective.

Prema Padmanabhan¹, Ahmed Elsheikh^2,3,4

¹Department of Cornea and Refractive Surgery, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Current Eye Research

|June 24, 2022

Summary

This summary is machine-generated.

Corneal biomechanics is crucial for understanding keratoconus progression. Advances in assessing these properties aid in early diagnosis and treatment of corneal ectasias, improving patient outcomes.

Keywords:

Corneal biomechanics biomechanical properties corneal ultrastructure keratoconus viscoelasticity

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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

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Area of Science:

Ophthalmology
Biomedical Engineering
Materials Science

Background:

Corneal biomechanics and ultrastructure are integral to corneal function and shape.
Keratoconus, a form of corneal ectasia, is characterized by biomechanical instability leading to progressive thinning and steepening.
Understanding the link between corneal structure, biomechanics, and optical function is key to managing ectatic diseases.

Purpose of the Study:

To provide an overview of research on the biomechanical aspects of keratoconus.
To highlight the growing recognition of corneal biomechanics in clinical assessments of corneal ectasias.
To review the literature predominantly from the last two decades on keratoconus biomechanics.

Main Methods:

A systematic review of published articles on corneal biomechanics and keratoconus.
Electronic searches were conducted using PubMed, Elsevier, and Science Direct.
Keywords included "Corneal Biomechanics," "Mechanical properties of the cornea," "Corneal ultrastructure," "Corneal Collagen," and "Keratoconus."

Main Results:

Over 500 articles were identified through the search.
80 relevant articles were selected for this review.
The review focuses on the biomechanical factors influencing keratoconus.

Conclusions:

Corneal stromal structure dictates its mechanical properties, maintaining corneal shape and function.
Alterations in corneal ultrastructure lead to biomechanical instability and ectasia.
Evolving non-invasive biomechanical assessment methods will improve early diagnosis of subclinical keratoconus and at-risk patients.