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Anagrelide-Induced Supraventricular Tachycardia: A Case Report

Faraz Badar1, Hayder Azeez2, Zeinab Abdulrahman2

  • 1Internal Medicine, Northwell Health, Port Jefferson, USA.

Cureus
|June 24, 2022
PubMed

Anagrelide is an inhibitor of the phosphodiesterase-3 (PDE-3) enzyme that suppresses megakaryocytes; hence it is used in the treatment of essential thrombocythemia. Anagrelide can cause positive inotropic and chronotropic effects on the cardiovascular system. Its cardiovascular side effects are rare and include palpitations, tachyarrhythmias, cardiomyopathy, angina, and heart failure. We report the case of a 71-year-old female who presented with sudden onset chest pain. Her only outpatient medications included anagrelide and aspirin. She was found to have supraventricular tachycardia (SVT) with aberrancy that responded to beta-blockers. The chest X-ray, computed tomography angiogram (CTA), and echocardiogram were unremarkable. Her arrhythmia may be attributed to the anagrelide in the absence of any cardiovascular findings.

Keywords:
anagrelidecardiac arrythmiajak-2: janus kinasemyeloproliferativethrombocythemia

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