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Updated: Sep 6, 2025
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed-Sternberg Cells in 10 High-Power
Dominique Fonseca Rodrigues Lacet1,2, Cristiano Claudino Oliveira1,3
1Department of Pathology, Botucatu School of Medicine, São Paulo State University (FMB UNESP), Belo Horizonte, Brazil.
Classical Hodgkin lymphoma (CHL) patients with CD20-positive cells show better outcomes. Specifically, fewer than 10.5 CD20-positive Reed-Sternberg cells per 10 high-power fields indicate a more favorable prognosis.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- CD20 immunoexpression in classical Hodgkin lymphoma (CHL) is variable.
- This expression may link CHL pathophysiology with patient prognosis.
Purpose of the Study:
- To investigate the association between CD20 expression and clinical outcomes in CHL patients.
Main Methods:
- Retrospective study of 174 CHL patients.
- Immunophenotypic analysis of CD20 expression using hotspot count and 10 high-power fields (HPF).
- Clinical data reviewed from medical records.
Main Results:
- CD20-positive phenotype observed in 45 (25.9%) of patients.
- CD20 positivity on neoplastic cells correlated with earlier healing.
- Less than 10.5 CD20-positive cells/10 HPF was significantly associated with better prognosis (p=0.037).
Conclusions:
- CD20 expression in CHL is a potential prognostic marker.
- Lower levels of CD20-positive Reed-Sternberg cells suggest a better clinical outcome for CHL patients.
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