Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

4.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.4K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.6K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
Bone Remodeling01:40

Bone Remodeling

38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship between the metabolic syndrome and its components and bone status in postmenopausal women.

Acta physiologica Hungarica·2014
Same author

Bone metabolism regulators and arterial stiffness in postmenopausal women.

Maturitas·2013
Same author

Arterial stiffness, carotid atherosclerosis and left ventricular diastolic dysfunction in postmenopausal women.

European journal of internal medicine·2013
Same author

Factors affecting early morbidity and mortality in non-small cell lung cancer surgery, the experience of Surgical Clinic No. 1, Tg. Mureş.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2011
Same author

Carotid arterial stiffness in patients with chronic obstructive pulmonary disease.

Acta physiologica Hungarica·2011
Same author

Vitamin K and vascular calcifications.

Acta physiologica Hungarica·2010

Related Experiment Video

Updated: Sep 6, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.6K

Relationship between Osteopontin and Bone Mineral Density.

A Vancea1, O Serban1, D Fodor1

  • 1"Iuliu Hațieganu" University of Medicine and Pharmacy, 2 Internal Medicine Department, Cluj-Napoca, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 24, 2022
PubMed
Summary

Osteopontin (OPN) shows promise as an early diagnostic biomarker for osteoporosis. Elevated serum OPN levels may indicate reduced bone mineral density (BMD) in postmenopausal women, aiding early osteoporosis detection.

Keywords:
BMIbone mineral densityosteopontinosteoporotic fracture

More Related Videos

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K
Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

823

Related Experiment Videos

Last Updated: Sep 6, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.6K
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K
Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

823

Area of Science:

  • Biochemistry
  • Orthopedics
  • Endocrinology

Background:

  • Osteopontin (OPN) is implicated in bone metabolism.
  • Its role as an early diagnostic marker for bone disorders requires clarification.
  • Bone mineral density (BMD) is a key indicator for osteoporosis development.

Purpose of the Study:

  • To systematically review the literature on the relationship between osteopontin and bone mineral density.
  • To evaluate osteopontin as a potential early diagnostic biomarker for osteoporosis.

Main Methods:

  • Systematic literature search of clinical trials.
  • PubMed database search (1999-2020).
  • Analysis of 7 eligible studies focusing on human subjects.

Main Results:

  • Identified 7 clinical trials examining osteopontin and BMD.
  • Found a potential association between serum OPN levels and BMD.
  • Highlighted the need to reconcile conflicting literature findings.

Conclusions:

  • Serum osteopontin (OPN) may serve as a valuable biomarker for early osteoporosis diagnosis.
  • This is particularly relevant for postmenopausal women, irrespective of vertebral fractures.
  • Further research is warranted to confirm OPN's role in osteoporosis management.