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CLINICAL FEATURES OF HYPERCALCEMIC CRISIS IN PRIMARY HYPERPARATHYROIDISM
U Turan1, H Kilavuz1, O Irkorucu2
1Adana City Training and Research Hospital, Department of General Surgery, Adana, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 24, 2022
Summary
Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a serious condition. Early identification of PHHC in patients with high calcium, PTH, ALP, and creatinine levels is crucial for timely, life-saving treatment.
Area of Science:
- Endocrinology
- Surgical Oncology
Background:
- Primary hyperparathyroidism related hypercalcemic crisis (PHHC) can be fatal.
- Early diagnosis and prompt treatment are vital for patient outcomes.
Purpose of the Study:
- To identify clinical features differentiating hypercalcemic crisis (HC) in primary hyperparathyroidism (PH) patients.
- To compare clinical and biochemical profiles of PH patients with and without HC.
Main Methods:
- Retrospective study of 119 patients operated for PH between March 2015 and March 2020.
- Patients were divided into HC (serum calcium > 14 mg/dl) and non-HC groups.
- Comparison of demographic, biochemical, localization, histopathological, and postoperative data.
Main Results:
- HC group showed significantly higher serum Parathormone (PTH), calcium (Ca), Alkaline phosphatase (ALP), and creatinine levels.
- Hyper-functional parathyroid tumor size was significantly larger in the HC group.
- No significant differences were found in demographic, histopathological, localization, or postoperative outcomes.
Conclusions:
- PHHC requires more urgent treatment than elective PH surgery due to its potential mortality.
- Prioritize PH patients with elevated serum PTH, ALP, creatinine, and larger parathyroid tumors for prompt treatment to mitigate HC risk.
Keywords:
hypercalcemiahypercalcemic crisishyperparathyroid crisisparathyroidectomyprimary hyperparathyroidismMore Related Videos
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