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Probable Cerebral Amyloid Angiopathy-Related Inflammation Associated With Sitravatinib: A Case Report
Christopher Ray1, Kalen Dionne1
1Department of Neurology, Washington University School of Medicine.
Background And Objectives:
We present the case of a 67-year-old man who developed encephalopathy, headaches, and seizure activity after initiating treatment with the novel tyrosine kinase inhibitor, sitravatinib.
Methods:
The patient was identified in routine clinical practice.
Results:
Brain MRI revealed lobar microhemorrhages and bihemispheric vasogenic edema. The patient met the criteria for probable cerebral amyloid angiopathy-related inflammation (CAA-ri) and responded favorably to high-dose methylprednisolone.
Discussion:
This report of neurologic autoimmunity in a patient receiving sitravatinib opens new lines of inquiry into the pathophysiology of CAA-ri. We emphasize the importance of early recognition and treatment of CAA-ri among patients receiving immunomodulatory chemotherapy.
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