Related Experiment Video
Updated: Sep 6, 2025
11:26
Sequencing of mRNA from Whole Blood using Nanopore Sequencing
Published on: June 3, 2019
13.9K
Nanopore Sequencing Technology in Oral Oncology: A Comprehensive Insight
Dominic Augustine1, S V Sowmya1, Vanishri C Haragannavar1
1Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
The Journal of Contemporary Dental Practice
|June 24, 2022
Summary
Nanopore sequencing offers a cost-effective and rapid method for analyzing oral cancer genomes. This technology aids in understanding oral cancer
Area of Science:
- Genomics
- Oncology
- Molecular Biology
Background:
- Oral cancer arises from genetic aberrations, necessitating deeper genomic research.
- Nanopore sequencing technology (NPST) offers potential for detecting genomic alterations.
- This review explores NPST's role in oral oncology.
Purpose of the Study:
- To review the principles and applications of Nanopore Sequencing Technology (NPST) in oral cancer.
- To highlight NPST's utility in identifying malignancy behavior and guiding research.
Main Methods:
- Literature search of PubMed and internet sources (2008-2020).
- Keywords included "nanopore sequencing," "oral squamous cell carcinoma," "genetic," "epigenetic," and "oncogenic viruses."
- Findings synthesized focusing on gene mutations, epigenetic alterations, and viruses in oral cancer.
Main Results:
- Nanopore sequencing is cost-effective and provides rapid turnaround times.
- It is a valuable platform for resolving ambiguities in genomes, epigenomes, and transcriptomes.
Conclusions:
- NPST adoption is encouraged for oral cancer research and management.
- The technology can aid in diagnosing oral cancer and personalizing treatment strategies.
Related Concept Videos
03:21RNA-seq
10.4K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.4K
03:00Next-generation Sequencing
92.5K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
92.5K