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The link between cutaneous inflammation and cognitive impairment.

S Wen¹, P M Elias^2,3, J S Wakefield^2,3

¹Dermatology Hospital, Southern Medical University, Guangdong, China.

Journal of the European Academy of Dermatology and Venereology : JEADV

|June 24, 2022

Summary

Cognitive decline is linked to skin inflammation, particularly in aging individuals. Improving skin health may help mitigate age-related cognitive impairment and reduce inflammation.

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Area of Science:

Neuroscience
Dermatology
Gerontology

Background:

Cognitive impairment, including dementia and Alzheimer's disease, is prevalent in aging populations.
Systemic disorders like cardiovascular disease and diabetes exacerbate cognitive decline.
Inflammatory skin conditions, such as psoriasis and eczema, are associated with higher rates of cognitive impairment.

Purpose of the Study:

To explore the link between cutaneous inflammation and cognitive impairment.
To investigate the role of epidermal dysfunction in age-related inflammation ('inflammaging').
To assess the potential of improving epidermal function to mitigate cognitive decline.

Main Methods:

Review of epidemiological studies on cognitive impairment and inflammatory skin disorders.
Analysis of the relationship between chronological aging, cutaneous inflammation, and circulating cytokines.
Examination of the impact of epidermal function on inflammation and cognitive health.

Main Results:

Aging is associated with increased skin inflammation and elevated cytokine levels.
Epidermal dysfunction contributes to chronic low-grade inflammation ('inflammaging').
Evidence suggests a connection between inflammatory skin diseases and cognitive impairment.

Conclusions:

Epidermal dysfunction may play a role in age-related cognitive decline.
Improving epidermal function could be a novel strategy to combat cognitive impairment in aging.
Targeting skin health may offer a new therapeutic avenue for neurological health in the elderly.