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Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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Related Experiment Video

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Formation of Dispersible Taohong Siwu Tablets

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Published on: February 3, 2023

Formulation, Development, and in-vitro Evaluation of Escitalopram Fast Dissolving Tablets.

Vishal Bhatia¹, Ashwani K Dhingra¹, Rameshwar Dass¹

¹Department of Pharmacy, Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, India.

Central Nervous System Agents in Medicinal Chemistry

|June 24, 2022

Summary

This study developed fast-dissolving tablets (FDTs) for escitalopram, enhancing its dissolution and bioavailability. The novel formulation shows promise for treating depression by enabling rapid drug release.

Keywords:

Co-processed excipients bioavailability depression escitalopram banana powder fast-dissolving tablets microcrystalline cellulose

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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Escitalopram, a selective serotonin reuptuptake inhibitor (SSRI), faces challenges in oral drug delivery due to poor water solubility and slow dissolution rates.
This limitation hinders effective management of depression and anxiety disorders, impacting therapeutic outcomes.

Purpose of the Study:

To develop a novel fast-dissolving tablet (FDT) formulation of escitalopram.
To enhance the dissolution profile and bioavailability of escitalopram for improved therapeutic efficacy.

Main Methods:

Utilized co-processed excipients, specifically a blend of banana powder and microcrystalline cellulose, to improve tablet properties.
Employed a direct compression technique and a randomized central composite design for tablet manufacturing.
Investigated the impact of these excipients on compressibility, disintegration, and drug release.

Main Results:

The developed fast-dissolving tablets demonstrated rapid drug release, with over 95% of escitalopram released within 10 minutes.
Exhibited a significantly improved in-vitro drug release profile compared to existing marketed formulations.
Confirmed enhanced bioavailability potential through in-vitro assessments.

Conclusions:

The novel fast-dissolving escitalopram formulation shows promising in-vitro results.
This formulation may offer a beneficial treatment option for acute depressive episodes by ensuring rapid therapeutic drug concentrations.
Further in-vivo studies are warranted to confirm clinical efficacy.