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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Controlled Bioactive Delivery Using Degradable Electroactive Polymers.

Mark D Ashton1, Patricia A Cooper2, Sofia Municoy3

  • 1Department of Chemistry, Faculty of Science and Technology, Lancaster University, Bailrigg, Lancaster LA1 4YB, U.K.

Biomacromolecules
|June 24, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed new degradable electroactive polymers for controlled drug delivery. These smart biomaterials enhance drug release when an electrical stimulus is applied, showing promise for advanced medical devices.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Controlled release biomaterials are crucial for agriscience and healthcare.
  • Existing materials often lack precise control over molecular delivery.
  • Electroactive polymers offer potential for stimuli-responsive applications.

Purpose of the Study:

  • To develop degradable electroactive polymers for controlled drug delivery.
  • To investigate the application of these polymers for delivering dexamethasone phosphate (DMP).
  • To evaluate the stimuli-responsive release characteristics of the developed materials.

Main Methods:

  • Synthesis of electroactive copolymers from polycaprolactone (PCL) and natural pyrrole oligomers (bilirubin, biliverdin, hemin).
  • Fabrication of polymer films, some doped with dexamethasone phosphate (DMP).
  • In silico, in vitro, and in vivo studies to assess cytocompatibility and drug release.

Main Results:

  • Developed cytocompatible degradable electroactive copolymers.
  • Demonstrated enhanced release of DMP (10-30%) upon electrical stimulation compared to passive release.
  • Confirmed stimuli-responsive drug delivery capabilities in vitro.

Conclusions:

  • Degradable electroactive polymers show promise for controlled molecular delivery.
  • Electrical stimulation significantly enhances drug release from these biomaterials.
  • Potential for integration into devices for technical and medical applications requiring precise molecule delivery.