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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Sep 6, 2025

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming.

Emilie M Legault¹, Julie Bouquety¹, Janelle Drouin-Ouellet¹

¹Faculty of Pharmacy, Université de Montréal, Montreal, Canada.

Cellular Reprogramming

|June 24, 2022

Summary

This summary is machine-generated.

Direct neural reprogramming offers a novel method to study neurodegenerative diseases like Alzheimer's and Parkinson's by generating patient-specific neural cells for molecular analysis.

Keywords:

direct neural reprogramming disease modeling iPSCs induced neurons neurodegenerative diseases

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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Area of Science:

Neuroscience
Stem Cell Biology
Genetics

Background:

Studying central nervous system (CNS) diseases is challenging due to limited access to patient brain tissue for molecular analysis.
Patient-derived induced pluripotent stem cells (iPSCs) offer a valuable tool for neurological disease research, particularly for monogenic disorders.
Direct reprogramming provides an alternative to iPSCs for generating specific neural cell types.

Purpose of the Study:

To review studies utilizing direct neural reprogramming for investigating neurodegenerative disease phenotypes.
To highlight the application of direct reprogramming in modeling Alzheimer's, Parkinson's, and ALS.
To discuss the potential of direct reprogramming in advancing CNS disease research.

Main Methods:

Review of scientific literature on direct neural reprogramming techniques.
Analysis of studies applying direct reprogramming to model neurodegenerative diseases.
Focus on generating neurons, astrocytes, and oligodendrocytes from somatic cells.

Main Results:

Direct neural reprogramming effectively generates patient-specific neural cells.
This method allows for the study of disease-associated molecular phenotypes in vitro.
Successful application in modeling key neurodegenerative conditions.

Conclusions:

Direct neural reprogramming is a powerful alternative to iPSCs for neurological disease modeling.
It facilitates the investigation of pathophysiology in Alzheimer's, Parkinson's, and ALS.
This approach holds significant promise for future CNS disease research and therapeutic development.