Related Experiment Video
Updated: Sep 6, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
Training the host organism to enhance anti-cancer immunity
Miriam Ferrer1, Tobias Janowitz2
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; MRC Cancer Unit, University of Cambridge, Cambridge, UK.
Abstract:
In this issue of Cancer Cell, Kurz et al. demonstrate in an orthotopic pancreatic cancer model that low-intensity exercise improves tumor control and response to immunotherapy in an IL-15-dependent manner. Combination therapy, IL-15 super-agonist, anti-PD-1 antibody and chemotherapy, strongly reduces tumor growth. Therefore, the study opens rich translational avenues.
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