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A structural and functional subdivision in central orbitofrontal cortex.

Maya Zhe Wang1,2, Benjamin Y Hayden3,4, Sarah R Heilbronner3

  • 1Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA. mayawangz@gmail.com.

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|June 24, 2022
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Summary
This summary is machine-generated.

The central orbitofrontal cortex (cOFC) is not a single region but has distinct medial (cOFCm) and lateral (cOFCl) parts. The cOFCm-posterior cingulate cortex (PCC) circuit is crucial for economic choice signals.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Neuroanatomy

Background:

  • Economic choices involve complex cognitive functions like stimulus detection and valuation.
  • The central orbitofrontal cortex (cOFC) has been traditionally viewed as a unified region responsible for these functions.

Purpose of the Study:

  • To challenge the unified view of the cOFC by investigating its subregions and their distinct roles.
  • To explore the anatomical and functional differentiation within the cOFC in rhesus macaques.

Main Methods:

  • Anatomical tract tracing to map connectivity between cOFC subregions and the posterior cingulate cortex (PCC).
  • Electrophysiological recordings to assess functional connectivity (spike-field coherence, mutual information) between cOFC and PCC.

Main Results:

  • The cOFC can be subdivided into medial (cOFCm) and lateral (cOFCl) regions based on differential connectivity with the PCC.
  • The cOFCm exhibits stronger functional connectivity with the PCC compared to cOFCl.
  • The cOFCm-PCC circuit, unlike the cOFCl-PCC circuit, appears to relay choice signals and exhibits a mutually excitatory pattern.

Conclusions:

  • The central orbitofrontal cortex is functionally heterogeneous, with distinct medial and lateral subregions.
  • The cOFCm-PCC pathway plays a specific role in processing economic choice information, differentiating between non-spatial and spatial frameworks.