Synthesis of asymmetric 1,4-disubstituted piperazines and their psychotropic and cardiovascular actions. Part I

New asymmetric piperazines 1-6 were obtained by condensation of 1-acylpiperazines with 1,2-epoxy-3-chloropropane, 1,2-epoxypropane, arylacid chlorides and secondary amines. The compounds displayed a biological activity: they depressed the central nervous system, altered the blood pressure, and one of them increased the coronary flow.