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Spouse bereavement and brain pathologies: A propensity score matching study
Jee Wook Kim1,2, Min Soo Byun3,4, Jun Ho Lee5
1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea.
Spouse bereavement, especially later in life, is linked to increased white matter hyperintensities, a marker of brain injury. This suggests a potential pathway to cognitive decline and dementia in older adults.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Spouse bereavement is a significant life stressor.
- It may accelerate cognitive decline and dementia.
- Underlying brain pathologies remain unclear.
Purpose of the Study:
- Investigate the association between spouse bereavement and in vivo brain pathologies.
- Examine if lifetime spouse bereavement impacts cognitive decline markers.
Main Methods:
- 319 older adults (61-90 years) underwent clinical assessments and multimodal brain imaging.
- Included PET scans (Pittsburgh compound B, AV-1451, fluorodeoxyglucose) and MRI.
- Propensity score matching compared 59 bereaved individuals with 59 controls.
Main Results:
- Spouse bereavement correlated with higher white matter hyperintensity (WMH) volume.
- This association was stronger in individuals over 75 and those with lower-skill occupations.
- Bereavement at age 60+ significantly impacted WMH, unlike younger bereavement.
Conclusions:
- Spouse bereavement may increase dementia risk via cerebrovascular injury (WMH).
- Older individuals and those with lower-skill occupations are particularly vulnerable.
- Findings highlight the impact of bereavement on brain health.
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