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miR-590-5p: A double-edged sword in the oncogenesis process
Tushar Singh Barwal1, Neha Singh2, Uttam Sharma2
1Department of Zoology, Central University of Punjab, Bathinda, 151401, Punjab, India; GreyB consultancy services, Mohali, Punjab 160062, India.
Cancer Treatment and Research Communications
|June 25, 2022
Summary
MicroRNA-590-5p (miR-590-5p) plays a complex, dual role in cancer, acting as both an oncogene and tumor suppressor. This review clarifies its paradoxical functions and involvement in cancer hallmarks.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MicroRNA-590-5p (miR-590-5p) is implicated in cellular homeostasis and cancer.
- miR-590-5p exhibits context-dependent roles, functioning as an oncogene in some cancers and a tumor suppressor in others.
Purpose of the Study:
- To systematically review the concept, mechanism, and biological function of miR-590-5p.
- To resolve the paradox of miR-590-5p's dual role in oncogenesis.
- To explore miR-590-5p's involvement in cancer hallmarks and identify potential targets.
Main Methods:
- Systematic literature review.
- Analysis of miR-590-5p's role in cancer hallmarks (proliferation, invasion, metastasis, chemo radioresistance).
- Bioinformatic analysis to predict miR-590-5p gene/pathway targets.
Main Results:
- miR-590-5p's function in cancer is complex and context-dependent, acting as a 'double-edged sword'.
- The microRNA is involved in key cancer processes including proliferation, invasion, metastasis, and resistance to therapy.
- Potential gene and pathway targets of miR-590-5p have been identified.
Conclusions:
- Understanding the paradoxical roles of miR-590-5p is crucial for cancer research.
- miR-590-5p's involvement in cancer hallmarks highlights its significance in oncogenesis.
- This review provides insights for developing novel cancer biomarkers and therapeutic strategies targeting miR-590-5p.
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