Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical and visual compatibility of dexmedetomidine injection with parenteral medications used in neonatal intensive care settings.

European journal of hospital pharmacy : science and practice·2026
Same author

Chemical and visual compatibility of fluconazole injection with parenteral medications used in neonatal intensive care settings.

European journal of hospital pharmacy : science and practice·2026
Same author

Cefazolin for Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia.

The New England journal of medicine·2026
Same author

Neonatal sepsis and cardiovascular dysfunction II: assessment.

Pediatric research·2026
Same author

Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Optimisation of the sampling method for skin microbiome studies in healthy children: a pilot cohort study.

Frontiers in microbiomes·2026

Related Experiment Video

Updated: Jun 9, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.2K

Neonatal Staphylococcus Aureus Sepsis: a 20-year Western Australian experience.

Rachel Shadbolt1, Michael Lee Shee We1, Rolland Kohan2,3,4

  • 1Medical School, University of Western Australia, Perth, WA, Australia.

Journal of Perinatology : Official Journal of the California Perinatal Association
|June 25, 2022
PubMed
Summary

Neonatal Staphylococcus aureus (SA) sepsis incidence decreased over 20 years in Western Australia. SA sepsis is linked to longer ventilation and poorer neurodevelopmental outcomes in infants.

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.5K
Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport
05:15

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

Published on: June 21, 2024

823

Related Experiment Videos

Last Updated: Jun 9, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.2K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.5K
Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport
05:15

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

Published on: June 21, 2024

823

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Neonatal sepsis remains a significant concern in intensive care settings.
  • Staphylococcus aureus (SA) is a common pathogen causing neonatal infections.
  • Understanding SA sepsis epidemiology and outcomes is crucial for improving infant care.

Purpose of the Study:

  • To characterize neonatal Staphylococcus aureus (SA) sepsis in Western Australia (WA) from 2001-2020.
  • To identify risk factors associated with SA sepsis in neonates.
  • To compare short- and long-term outcomes of SA sepsis with non-sepsis controls.

Main Methods:

  • Retrospective cohort study conducted at a tertiary neonatal intensive care unit.
  • Data sourced from electronic databases and patient medical records.
  • Analysis included incidence, risk factors, and short/long-term outcomes.

Main Results:

  • Overall SA sepsis incidence was 0.10 per 1000 live births, decreasing from 0.13/1000 (2001-2010) to 0.07/1000 (2011-2020).
  • Endotracheal aspirates were the most common source of SA isolation.
  • Infants with SA sepsis experienced longer ventilation (31 vs 18 days) and worse neurodevelopmental outcomes.

Conclusions:

  • Neonatal SA sepsis incidence has declined, potentially due to preventative measures.
  • Endotracheal tube colonization and prolonged ventilation are potential SA infection sources.
  • SA sepsis is associated with adverse neurodevelopmental impacts in neonates.