Urinary anti diuretic hormone level in essential hypertension

The present study was aimed to examine the excretory urinary Anti Diuretic Hormone (ADH) pattern in five normotensive and ten hypertensive human subjects. It was observed that Essential hypertensive subjects excreted higher urinary ADH 8.03 +/- 1.17 mU/hr as compared to 3.60 +/- 0.72 mU/hr the difference between the two groups being statistically significant (P less than 0.01). Various renal function parameters evaluated were within normal limits. The results of this study suggest the involvement of ADH in the pathophysiology of Essential hypertension.