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Antihypertensive Drugs and Risk of Bone Fractures
Maria Velliou1, Elias Sanidas2, Aliki Zografou3
1Emergency Medicine Department, Attikon University Hospital, Athens, Greece. maravelliou84@yahoo.gr.
Abstract:
Antihypertensive drugs are among the most documented regimens worldwide with an overall survival and cardioprotective benefit. However, there is evidence that they cause symptoms of orthostatic hypotension (i.e., dizziness and syncope) placing patients at risk for falls and fall-related injuries such as bone fractures. Moreover, it seems that they might impact bone metabolism and architecture impairing bone health. The aim of this review was to summarize the accumulative literature exploring any potential association between several antihypertensive medications including diuretics, renin-angiotensin-aldosterone system inhibitors, beta-blockers and calcium channel blockers and the risk of fractures.
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