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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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Translational Regulation01:29

Translational Regulation

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Ribosomal RNA Synthesis02:53

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

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Non-coding RNAs in Neonatal Necrotizing Enterocolitis.

Keyur Donda1, Benjamin A Torres1, Akhil Maheshwari2

  • 1Department of Pediatrics, University of South Florida Health Morsani College of Medicine, Tampa, Florida, United States of America.

Newborn (Clarksville, Md.)
|June 27, 2022
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) lacks effective treatments due to poor understanding. Non-coding RNAs (ncRNAs) show promise for preventing, detecting, and treating NEC, offering new research avenues.

Keywords:
Genetic predispositionIntestinal inflammationNecrotizing enterocolitisNeonatesNon-coding RNASpontaneous intestinal perforation

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Area of Science:

  • Molecular Biology
  • Gastroenterology
  • Developmental Biology

Background:

  • Necrotizing enterocolitis (NEC) pathogenesis is poorly understood, hindering diagnosis and treatment.
  • Non-coding RNAs (ncRNAs) regulate gene expression and are implicated in inflammatory diseases.
  • The role of ncRNAs in NEC remains largely unexplored.

Purpose of the Study:

  • To review current knowledge on ncRNAs in NEC.
  • To explore ncRNAs identified in NEC and related inflammatory bowel disorders.
  • To highlight the potential of ncRNAs for NEC research and clinical applications.

Main Methods:

  • Literature review of ncRNAs in NEC and similar inflammatory bowel disorders.
  • Assimilation of current research findings on ncRNAs in intestinal diseases.
  • Focus on ncRNAs with shared histopathological abnormalities with NEC.

Main Results:

  • ncRNAs are key gene expression regulators with potential roles in NEC.
  • Studies in adult inflammatory bowel diseases suggest ncRNA involvement.
  • Limited research exists specifically on ncRNAs in NEC.

Conclusions:

  • ncRNAs represent a novel and promising area for NEC research.
  • Further investigation into ncRNAs could lead to advancements in NEC prevention, diagnosis, and treatment.
  • Translational and clinical research in ncRNAs holds significant potential for NEC management.