Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hearing01:31

Hearing

48.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
48.1K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

798
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
798
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

810
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
810
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytomegalovirus and HIV Co-Infections During Pregnancy and Early Childhood.

Current HIV/AIDS reports·2026
Same author

Congenital cytomegalovirus and associations with maternal HIV serostatus and child health outcomes in Uganda.

BMC infectious diseases·2026
Same author

Advancements and potential in the prevention of congenital CMV infection.

Seminars in fetal & neonatal medicine·2025
Same author

Targeted RNA sequencing identified gene expression profiles linked to severe necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.

Research square·2025
Same author

Cytomegalovirus Saliva Shedding Kinetics in Children with Congenital CMV Infection.

Journal of the Pediatric Infectious Diseases Society·2025
Same author

Ginger: A Nutraceutical Supplement for Protection Against Various Cardiovascular Diseases in Clinical Trials.

Cureus·2025
Same journal

Milk Fat Globules: 2024 Updates.

Newborn (Clarksville, Md.)·2024
Same journal

Respiratory Syncytial Virus Infections in Neonates: A Persisting Problem.

Newborn (Clarksville, Md.)·2024
Same journal

Point-of-care Ultrasound to Diagnose and Monitor the Course of Necrotizing Enterocolitis.

Newborn (Clarksville, Md.)·2023
Same journal

Extrauterine Growth Restriction: Need for an Accurate Definition.

Newborn (Clarksville, Md.)·2023
Same journal

Clinical Correlates of Cholestasis in Preterm Infants with Surgical Necrotizing Enterocolitis.

Newborn (Clarksville, Md.)·2023
Same journal

Linked Th17 and Calgranulin Responses in Maternal-cord Blood Dyads of Preterm Gestations with Histologic Chorioamnionitis.

Newborn (Clarksville, Md.)·2023
See all related articles

Related Experiment Video

Updated: May 6, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

15.0K

CMV-induced Hearing Loss.

Srijan Singh1,2, Akhil Maheshwari2,3, Suresh Boppana4

  • 1Department of Neonatology, Kailash Hospital, Noida, Uttar Pradesh, India.

Newborn (Clarksville, Md.)
|February 13, 2024
PubMed
Summary
This summary is machine-generated.

Congenital cytomegalovirus (cCMV) is a leading cause of non-genetic childhood hearing loss. Early intervention and ongoing monitoring are crucial for affected infants, as hearing loss can be progressive.

Keywords:
ABR thresholdsAuditory brainstem response and otoacoustic emissionsAural preference syndromeBehavioral audiometryBetaherpesvirusBlood-labyrinth barrierCMV PCRCMV-specific hyperimmune globulinCerebellar hypoplasiaCerebral atrophyCochlear blood–labyrinth barrierCochlear implantCytomegalic inclusion diseaseCytomegalovirus (CMV)Dried blood spot (DBS)Endocochlear potentialFluctuating hearing lossGanciclovirHerpesviridaeHuman Herpes Virus 5Icosahedral capsidImpedance audiometryIntracranial calcificationsLenticulostriate vasculopathyMF59-adjuvanted CMV glycoprotein B subunit vaccineMigrational abnormalitiesNatural killerNeurotrophinsNewborn hearing screeningNlrp3Non-primary maternal infectionOrgan of cortiPeriventricular echo densityPlay audiometryPure tone audiometrySensorineural hearing loss (SNHL)SeroimmuneSpeech audiometrySpiral ganglion cellsSpiral ganglion neuronsStrain-specific epitopesStria vascularisTegument layerTympanometryUnique long gene regionUnique short gene regionValganciclovirVentricular adhesionsVentricular dilatationVentriculomegalyViral coreViral lipid bilayer envelopeViral matrixViral replication cycleVisual reinforcement audiometryWhite matter disease

More Related Videos

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

13.9K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.2K

Related Experiment Videos

Last Updated: May 6, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

15.0K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

13.9K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.2K

Area of Science:

  • Virology
  • Pediatrics
  • Audiology

Background:

  • Congenital cytomegalovirus (cCMV) is the most common fetal viral infection.
  • cCMV is the leading nongenetic cause of sensorineural hearing loss (SNHL) in children.
  • Even infants born to mothers with prior CMV exposure are at risk for SNHL.

Purpose of the Study:

  • To highlight the significant contribution of cCMV to childhood hearing loss.
  • To emphasize the importance of ongoing hearing monitoring beyond newborn screening.
  • To discuss management and prevention strategies for cCMV-induced hearing loss.

Main Methods:

  • Review of cCMV pathogenesis and clinical impact.
  • Analysis of hearing loss characteristics (delayed onset, progressive).
  • Evaluation of current and potential preventive measures and interventions.

Main Results:

  • cCMV accounts for approximately 25% of childhood hearing loss by age 4.
  • Hearing loss can be delayed, progressive, or fluctuating, often missed by newborn screening.
  • Multidisciplinary management, including hearing devices and early intervention, improves outcomes.

Conclusions:

  • Close, long-term hearing monitoring (until 5-6 years) is essential for infants with cCMV.
  • Assistive devices and early intervention services are vital for managing cCMV-related SNHL.
  • Preventive strategies, including potential vaccines and behavioral interventions, are critical to reduce intrauterine CMV transmission.