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Related Experiment Video

Updated: Sep 6, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Chronic lung allograft dysfunction.

Anupam Kumar1, Puneet Singh Garcha1

  • 1Baylor College of Medicine, 6720 Bertner Ave, Houston, TX 77030 USA.

Indian Journal of Thoracic and Cardiovascular Surgery
|June 27, 2022
PubMed
Summary
This summary is machine-generated.

Lung transplantation offers a cure for advanced lung disease, but chronic lung allograft dysfunction (CLAD) remains a major challenge. This review covers CLAD definitions, phenotypes, diagnosis, and management strategies for lung transplant recipients.

Keywords:
Chronic lung allograft dysfunctionChronic rejectionLung transplantation

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Area of Science:

  • Medical Science
  • Surgical Innovation
  • Immunology

Background:

  • Lung transplantation is a life-saving procedure for end-stage lung diseases.
  • Over 4000 lung transplants are performed globally each year.
  • Recipient survival has improved, but remains limited by complications.

Purpose of the Study:

  • To review the current understanding of chronic lung allograft dysfunction (CLAD).
  • To discuss the different clinical presentations (phenotypes) of CLAD.
  • To outline diagnostic and management tools for CLAD.

Main Methods:

  • Literature review of recent advancements in lung transplantation.
  • Analysis of data on recipient survival and causes of death.
  • Synthesis of information on CLAD definition, phenotypes, diagnosis, and management.

Main Results:

  • Chronic lung allograft dysfunction (CLAD) is the primary cause of death after one year post-transplant.
  • CLAD presents with various phenotypes, complicating diagnosis.
  • Effective diagnostic and management strategies are crucial for improving long-term outcomes.

Conclusions:

  • Despite advances, CLAD significantly limits long-term success in lung transplantation.
  • A clear understanding of CLAD phenotypes is essential for timely diagnosis.
  • Further research and optimized management are needed to combat CLAD and improve patient survival.