Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

21
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
21
Transcytosis of IgG01:15

Transcytosis of IgG

2.9K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.9K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

20
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

22
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
22
Autoimmune Disorders01:29

Autoimmune Disorders

661
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
661
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

23
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Prevalence and Consequences of Supra-Normal Estimated Glomerular Filtration Rate in Pediatric Solid Organ Transplants: A Single Center Cohort.

Transplantation proceedings·2026
Same author

Spitz Nevi With Novel BRAF Fusions: A Report of Two Cases With Striking Morphologic Features.

The American Journal of dermatopathology·2026
Same author

Venetoclax and azacitidine for younger acute myeloid leukemia patients independent of fitness for intensive chemotherapy.

Haematologica·2026
Same author

Alporting Trouble Down the Tubules.

Kidney international reports·2026
Same author

Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Pediatric Patients Undergoing Enterocystoplasty and Risk of Metabolic Disease: A Single Center Retrospective Study.

Neurourology and urodynamics·2025
Same journal

Establishment of a CT-based prediction model for endotracheal tube size in infants aged <1 year.

Frontiers in pediatrics·2026
Same journal

Case Report: Subcutaneous sensor-augmented insulin pump therapy in a 510-g preterm infant with hyperglycemia.

Frontiers in pediatrics·2026
Same journal

Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study.

Frontiers in pediatrics·2026
Same journal

Clinical and imaging features of tufted angioma in children.

Frontiers in pediatrics·2026
Same journal

Transcriptome-Inferred metabolic subtypes define prognostic and immune ecosystems in osteosarcoma at single-cell resolution.

Frontiers in pediatrics·2026
Same journal

Efficacy and anthropometric predictors of negative-pressure therapy for recurrent concealed penis in pediatric patients.

Frontiers in pediatrics·2026
See all related articles

Related Experiment Video

Updated: Sep 6, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K

Hypocomplementemic Atypical IgA Vasculitis: A Case Report.

Melvin Chan1, Melisha Gayle Hanna1, Nicholas Willard2

  • 1Department of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO, United States.

Frontiers in Pediatrics
|June 27, 2022
PubMed
Summary
This summary is machine-generated.

IgA vasculitis (IgAV) involves small vessel inflammation. This case report links IgAV to complement system abnormalities, suggesting complement-targeted therapies may benefit patients with severe kidney involvement.

Keywords:
HSPIgA vasculitiscase reporthypocomplementemiamembranoproliferative glomerulonephritis

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.3K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.7K

Related Experiment Videos

Last Updated: Sep 6, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.3K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.7K

Area of Science:

  • Nephrology
  • Immunology
  • Pediatrics

Background:

  • IgA vasculitis (IgAV), or Henoch-Schönlein purpura, is a systemic small vessel vasculitis.
  • The complement system's role in IgAV pathogenesis is suggested by lab studies but lacks direct clinical evidence.
  • Kidney involvement, including glomerulonephritis, is a significant complication of IgAV.

Observation:

  • A child with IgAV presented with hypertension, nephrotic-range proteinuria, and acute kidney injury.
  • Laboratory tests revealed low serum C3 levels.
  • Renal biopsy showed membranoproliferative glomerulonephritis with IgA and C3 co-deposition and complement abnormalities.

Findings:

  • This case demonstrates a direct association between IgA vasculitis and significant complement derangements in a pediatric patient.
  • The findings suggest the complement system plays a crucial role in the kidney pathology of IgAV.
  • Histopathology confirmed IgA and C3 co-dominance in the glomerulonephritis.

Implications:

  • Complement system activation appears to be a key factor in IgAV pathogenesis, particularly in severe kidney disease.
  • Targeting the complement system may offer a novel therapeutic strategy for refractory IgAV cases with renal complications.
  • Further research into complement-mediated pathways is warranted to optimize IgAV treatment.