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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: Sep 6, 2025

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Automated bone healing evaluation: New approach to histomorphometric analysis.

Camila Rodrigues Borges Linhares¹, Gustavo Davi Rabelo², Pedro Henrique Justino Oliveira Limirio¹

¹Dentistry Department, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.

Microscopy Research and Technique

|June 27, 2022

Summary

This summary is machine-generated.

A new automatic method for evaluating bone healing in histological images significantly reduces analysis time. This approach, tested on diabetic rats receiving hyperbaric oxygen therapy, proved accurate and efficient compared to traditional methods.

Keywords:

automated image analysis bone regeneration computer-assisted hyperbaric oxygenation type 1 diabetes mellitus

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Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Area of Science:

Regenerative Medicine
Biomedical Engineering
Histology and Pathology

Background:

Evaluating bone healing histologically is crucial for assessing therapeutic interventions.
Traditional methods like histomorphometry can be time-consuming and subjective.
Diabetes mellitus complicates bone healing, necessitating reliable evaluation techniques.

Purpose of the Study:

To compare different histological evaluation methods for bone healing.
To introduce and validate a novel, automated image analysis method for bone matrix quantification.
To assess the effect of hyperbaric oxygen therapy (HBO) on bone repair in diabetic rats.

Main Methods:

Induction of type 1 diabetes mellitus in rats using streptozotocin.
Creation of bone defects in femurs, followed by hyperbaric oxygen therapy (HBO).
Histological analysis using conventional histomorphometry, semi-automatic segmentation, and a new automatic ImageJ plug-in.

Main Results:

All three histological evaluation methods (conventional, semi-automatic, automatic) were statistically comparable in assessing bone formation.
The novel automatic approach significantly reduced analysis time compared to visual grid and semi-automated methods (p < .01).
Hyperbaric oxygen therapy showed potential in improving bone repair, particularly in diabetic models.

Conclusions:

The developed automatic method provides an accurate and highly efficient tool for histological bone healing evaluation.
This automated approach streamlines research by significantly shortening analysis duration.
The study demonstrates the utility of advanced image analysis in regenerative medicine and bone repair research.