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ABC transporters in breast cancer: their roles in multidrug resistance and beyond

Anupama Modi1, Dipayan Roy1,2, Shailja Sharma1

  • 1Department of Biochemistry, AIIMS, Jodhpur, India.

Journal of Drug Targeting
|June 27, 2022
PubMed

Insights

ATP-binding cassette (ABC) transporters are crucial in multidrug resistance and breast cancer (BC) progression. Targeting these transporters offers a promising strategy to improve BC treatment outcomes and patient prognosis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • ATP-binding cassette (ABC) transporters are membrane proteins critical for cellular transport.
  • These transporters are implicated in multidrug resistance (MDR) in cancer chemotherapy.
  • ABC transporters play significant roles in cancer pathogenesis, prognostics, and therapeutic response.

Purpose of the Study:

  • To provide a comprehensive review of ABC transporters and their specific roles in breast cancer (BC) drug resistance.
  • To highlight key ABC transporters involved in BC chemoresistance and prognosis.
  • To discuss emerging therapeutic strategies targeting ABC transporters in BC.

Main Methods:

  • Literature review of existing clinical and molecular evidence.
  • Analysis of ABC transporter expression in different BC subtypes and metastases.
  • Examination of therapeutic approaches targeting ABC transporters.

Main Results:

  • High expression of ABC transporters, including ABCA1, ABCB1, and ABCG2, is observed in less differentiated BC subtypes and metastases, contributing to chemoresistance.
  • ABCB1 and ABCC1 are identified as significant factors in BC prognosis.
  • Newer therapies aim to inhibit ABC transporters to overcome drug resistance, reduce cell viability, induce apoptosis, and enhance drug sensitivity.

Conclusions:

  • ABC transporters are key drivers of drug resistance and influence prognosis in breast cancer.
  • Inhibiting specific ABC transporters presents a viable strategy to reverse chemoresistance and improve treatment efficacy.
  • Future research focusing on targeted therapies for genetic variations and related molecules holds promise for enhancing patient outcomes in BC.
Keywords:
ABC transporterbreast cancerchemoresistancelncRNAmiRNApolymorphism

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