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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Related Experiment Video

Updated: Sep 6, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Ectopic Cavernous Sinus Microprolactinoma Treated Medically.

Robert M Minns1, Javier Barranco-Trabi1, Alvin C Yiu1

  • 1Department of Medicine, Tripler Army Medical Center, Honolulu, Hi 96859, USA.

Military Medicine
|June 27, 2022
PubMed
Summary
This summary is machine-generated.

Ectopic prolactin-secreting microadenomas, though rare, can be effectively managed with cabergoline medication. This case demonstrates successful treatment of a dopamine-resistant ectopic microprolactinoma, leading to symptom resolution and tumor reduction.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Ectopic prolactin-secreting microadenomas are rare pituitary tumors.
  • Management typically involves surgery, unlike common intrasellar prolactinomas.

Observation:

  • A 30-year-old male presented with erectile dysfunction and elevated prolactin levels.
  • Pituitary MRI revealed a 9mm microadenoma in the left cavernous sinus.

Findings:

  • Treatment with cabergoline, even at high doses, resolved symptoms and normalized prolactin levels.
  • The ectopic microprolactinoma showed significant size reduction and cystic degeneration.

Implications:

  • Medical management with cabergoline can be a successful alternative to surgery for ectopic prolactinomas.
  • This approach is effective even in cases of dopamine resistance, offering a less invasive treatment option.