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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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CLINICAL AND IMMUNOLOGICAL FEATURES OF ROTAVIRUS INFECTION IN CHILDREN INFECTED WITH EPSTEIN-BARR VIRUS
Marharyta Yu Sliepchenko1, Sergey V Kuznetsov1, Yana V Kolesnyk1
1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|June 27, 2022
Summary
Latent Epstein-Barr virus (EBV) infection alters rotavirus gastroenteritis in children, causing delayed hospitalization and prolonged symptoms. EBV also impacts immune cell profiles, with increased CD8+ T lymphocytes and decreased CD16+, CD22+ T lymphocytes and IgM.
Area of Science:
- Pediatrics
- Virology
- Immunology
Background:
- Rotavirus gastroenteritis is a common childhood illness.
- Epstein-Barr virus (EBV) is a widespread herpesvirus with a latent form.
- The interaction between rotavirus and latent EBV infections in children is not well understood.
Purpose of the Study:
- To investigate the clinical and immunological characteristics of acute rotavirus gastroenteritis in children with concurrent latent Epstein-Barr virus infection.
Main Methods:
- A comparative study of 56 children with rotavirus gastroenteritis.
- Group 1: 33 children without background infection.
- Group 2: 23 children with rotavirus infection on the background of latent EBV infection. Clinical data and immunological parameters (T lymphocyte subsets, IgM) were analyzed.
Main Results:
- Children with EBV coinfection experienced later hospitalization, reduced fever and vomiting, and prolonged fever and diarrhea.
- Immunologically, EBV coinfection was associated with a higher relative count of CD8+ T lymphocytes.
- A decreased relative content of CD16+, CD22+ T lymphocytes and IgM was observed during early convalescence in the EBV-coinfected group.
Conclusions:
- Latent EBV infection significantly influences the clinical presentation and immunological response in children with rotavirus gastroenteritis.
- Understanding these interactions is crucial for managing pediatric gastroenteritis in the context of EBV.
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